Green Bay (3-3) and Indianapolis (3-2) are set for what should be a great game. Green Bay has the 7th-Ranked Pass Defense in the NFL at 178.8 Yards per game, while Indianapolis has the 7th-Ranked Passing Offense (248 YPG) this year.
If Indianapolis hopes to pull out a victory, they need to do it on the ground, where the Packers are ranked 26th at 153.3 Yards allowed per game. However, Indianapolis is without Joseph Addai, which is why this should be a great game. The Packers lead the League in Interceptions (Tied with Tampa Bay at 11), and they are holding opposing QB's to a rating of 62.3 (3rd Best in the League).
I believe the Packers' pass defense, while missing a few key players, will still be able to keep Peyton Manning under control, and their defense will win them this game. If the Colts had Joseph Addai, I'd give the edge to Indianapolis, however, Dominic Rhodes is starting, and while he's proven to be a good backup, he's not as good as Joseph Addai.
Final Score: Green Bay 24, Indianapolis 21